tag:blogger.com,1999:blog-827769867360256958.post1771375004474228255..comments2024-01-14T03:16:09.597-08:00Comments on Kindke's Scrap Notes: JJ's Insulin Paper and beta-cell expansionKindkehttp://www.blogger.com/profile/15841418412425329998noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-827769867360256958.post-47518993766533382522013-02-03T05:58:43.699-08:002013-02-03T05:58:43.699-08:00Just a spelling correction.
By now it seems pointl...Just a spelling correction.<br /><i>By now it seems pointless, everything that could <b>have</b> been discussed...</i><br />In comments I don't mind, in a blog entry it's a more serious thing.gallier2https://www.blogger.com/profile/04285836062429366578noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-75436800755427366232013-01-25T20:09:44.621-08:002013-01-25T20:09:44.621-08:00I wonder, how does the higher fasting blood sugar ...I wonder, how does the higher fasting blood sugar as a result of adaptation to the low-carb diet fits the picture. Could it be the sign of diminishing insulin production, because higher insulin will probably inhibit glyconeogenesis? After 5 years of LCarbing, I am not so hungry as before after eating carbs, just experience a post-meal lethargy.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-61726049908545393432013-01-19T14:28:47.310-08:002013-01-19T14:28:47.310-08:00It has been enjoyable for me to interact with so m...It has been enjoyable for me to interact with so many interested and interesting people in the blogs. It gets me thinking outside the classroom, which I think is good. <br /><br />The beta-cell mass issue is a big one, and I hope to get some more answers in this area in the coming years (science is slow). <br /><br />As far as leptin, I'm not a 'world-leading' expert in this area, but I do know that it is a lot more complicated than even most scientists and MDs appreciate. My friend and colleague Dr. Kieffer has some great stuff on its roles in glucose homeostasis, which appear to be at least partially distinct from its roles in food intake. Interestingly, he and others have identified links between leptin-deficiency and hyperinsulinemia.JJhttps://www.blogger.com/profile/07501870312124387130noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-54279469112312075982013-01-19T12:36:11.942-08:002013-01-19T12:36:11.942-08:00Oh hi JJ!
Part of my motivation for making this ...Oh hi JJ! <br /><br />Part of my motivation for making this post is because those of us who have lost weight following a lowcarb/ketogenic diet are all to aware that in a weight-reduced state we remain incredibly vulnerable to weight regain as soon as we start to add back carbohydrates. Particularly those that spike blood sugar like potato/rice.<br /><br />Theres lots of possible reasons for this, with the leading contender being leptin insufficiency. After reading your paper I had the idea that a pancreas that is aggressive for beta-cell expansion and insulin hyper-secretion may be another reason for the increased susceptibility for weight regain in response to carbs.<br /><br />Anyway, Big thanks for your comment. I read your comments on the other blogs and certainly learned alot :)<br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-37422640128223027552013-01-19T11:04:04.475-08:002013-01-19T11:04:04.475-08:00And, the reversibility of the changes in beta-cell...And, the reversibility of the changes in beta-cell mass are very poorly understood. I think there are data from the Weir group at Joslin that indicate that if you transplant islets into a rat, the rat's own islets will shrink. I believe they attribute this to glucose rather than insulin though. The debate between the effects of glucose and insulin on beta-cell proliferation and mass is a very testy one in diabetes research circles. For a long time I was on the unpopular side of this debate, but I think the pendulum is swinging.JJhttps://www.blogger.com/profile/07501870312124387130noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-53855859787731900862013-01-19T11:01:10.333-08:002013-01-19T11:01:10.333-08:00Hi Kindke,
Thanks for your insightful post on the...Hi Kindke,<br /><br />Thanks for your insightful post on the paper. It turned up when I was Googling something else. Anyway, I think you have noticed what I personally think is one of the most interesting aspects of the results. The study of the effects of insulin on beta-cell survival and proliferation is something I have written a large number of papers on in the past (e.g. Johnson et al PNAS 2006; Beith et al Endocrinology 2008; Alejandro et al Endocrinology 2010) and it was actually the original motivation for the study - the analysis of obesity and fat reprogramming was actually a secondary endpoint.<br /><br />The long-term effects of diets on beta-cell mass is an area that needs lots more investigation. Although beta-cell mass increases with obesity in humans, no one has any idea whether some diets have more significant or durable effects. We are planning to do exactly that study in mice. As you probably know, the Cell Metabolism paper was not designed with diets in mind - we just used a diet we knew would increase insulin in male mice. We (or some other group) needs to redo the study with better matched and controlled diets in order to get answers on carbs vs fat.<br /><br />Cheers,<br /><br />JimJJhttps://www.blogger.com/profile/07501870312124387130noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-68375051818030151112013-01-16T07:15:27.700-08:002013-01-16T07:15:27.700-08:00imo that is backwards thinking, is the case of dia...imo that is backwards thinking, is the case of diabesity, they got IR in the first place because they got fat, and they got fat because insulin production started snowballing upwards. And this started to happen because of hepatic insulin resistance + high GI/carb dense foods allowing blood sugar to spike progressively more aggressively.<br /><br />These people do not need insulin therapy, they need to stop spiking their blood sugar so that the requirements for insulin go down and the bodies homeostatic systems can normalize.Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-15530448374883614912013-01-16T04:09:25.313-08:002013-01-16T04:09:25.313-08:00Maybe that’s why some diabetics put on insulin the...Maybe that’s why some diabetics put on insulin therapy early seem to recover some of their own insulin production.<br />Samhttps://www.blogger.com/profile/02872074976915798124noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-36266094692587085062013-01-15T11:06:14.145-08:002013-01-15T11:06:14.145-08:00Epic.
And yes, your last paragraph is crucial bec...Epic.<br /><br />And yes, your last paragraph is crucial because for all the health benefits of glucose restriction, it only really side-steps the problem. Obesity cannot be cured, it's an intractable illness. You can eat LC for a long time and normalise all your parameters but you are not cured; all it takes is just one meal of pizza or baked potato to send you spiking your BG and insulin again.Anonymousnoreply@blogger.com