tag:blogger.com,1999:blog-827769867360256958.post405870308702082912..comments2024-01-14T03:16:09.597-08:00Comments on Kindke's Scrap Notes: Slept well last nightKindkehttp://www.blogger.com/profile/15841418412425329998noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-827769867360256958.post-81988538404899444092013-04-20T02:36:07.313-07:002013-04-20T02:36:07.313-07:00Oh Kindke, you are an idealist. Now why would rese...Oh Kindke, you are an idealist. Now why would researchers focus on the really important and practical stuff? :)<br /><br />Still no time to read the paper, but I will get back to this.. What kills me is that no angiogenesis at all, "adipostat" or what its called, will kill off WAT, but increasing angiogenesis, too, can help getting rid of WAT.. Lucky us that we now a blogger whos hypothesis explains that all. FOOD REWARD.Purposelessnesshttps://www.blogger.com/profile/05310957056111105419noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-78099061230151561262013-04-19T12:54:11.111-07:002013-04-19T12:54:11.111-07:00Ive seen this paper before, its way off the beaten...Ive seen this paper before, its way off the beaten track. Something to do with hypoxia during expanding adipose tissue, hypoxia increases mitochondrial dysfunction which in turns induces apoptosis. I think thats how it goes.<br /><br />Angiogenesis is also involved, expanding adipose tissue needs angiogenesis to support it, otherwise adipocytes that are poorly innervated by blood capillaries experience hypoxia.<br /><br />What the researchers REALLY need to ask themselves is,... why is the adipose tissue expanding in the first place?<br /><br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-46480468710046850442013-04-19T06:21:47.245-07:002013-04-19T06:21:47.245-07:00Haven't read the paper beyond the abstract yet...Haven't read the paper beyond the abstract yet, but sharing is caring! Also, wtf? --><br /><br />"Genetic inactivation of Bid, a key pro-apoptotic<br />molecule that serves as a link between these two cell death path-<br />ways, significantly reduced caspase activation, adipocyte apoptosis,<br />prevented adipose tissue macrophage infiltration, and protected<br />against the development of systemic insulin resistance and hepatic<br />steatosis independent of body weight. <b>These data strongly suggest<br />that adipocyte apoptosis is a key initial event that contributes to<br />macrophage infiltration into adipose tissue, insulin resistance, and<br />hepatic steatosis associated with obesity in both mice and<br />humans.</b> Inhibition of adipocyte apoptosis may be a new thera-<br />peutic strategy for the treatment of obesity-associated meta-<br />bolic complications."<br /><br />Link to pdf: http://www.jbc.org/content/285/5/3428.full.pdfPurposelessnesshttps://www.blogger.com/profile/05310957056111105419noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-53935202042759687632013-04-15T20:13:44.621-07:002013-04-15T20:13:44.621-07:00I enjoy your POV - and I think that's a value ...I enjoy your POV - and I think that's a value often overlooked as we read many of the same materials and discuss them. All of focus/have the little light bulb come on over different things, based on our own histories and situations. Talking those through is extremely valuable, IMHO. It's not just N=1 but N=1 with respect to this item, where noted these other items. <br /><br />In that way, we get a richness of context we'd otherwise miss, I think. <br /><br />Perhaps a good forum would serve the same purpose ... but I think in the end it would be shallower.<br /><br />I hope you can keep contributing to the dialog, in whatever form fills your needs. annleehttps://www.blogger.com/profile/17666381399321975755noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-81827368547867772382013-04-14T09:21:25.317-07:002013-04-14T09:21:25.317-07:009 mg of melatonin. :o I thought I had bad insomnia...9 mg of melatonin. :o I thought I had bad insomnia.<br /><br />I feel the same way about blogging.Anonymousnoreply@blogger.com