tag:blogger.com,1999:blog-827769867360256958.post6326805578388324079..comments2024-01-14T03:16:09.597-08:00Comments on Kindke's Scrap Notes: Obesity isnt "normal" Kindkehttp://www.blogger.com/profile/15841418412425329998noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-827769867360256958.post-88697328412913878862015-05-31T19:04:51.330-07:002015-05-31T19:04:51.330-07:00From my experience, fasts make liver very efficien...From my experience, fasts make liver very efficient in a glyconeogenesis. May be some fat sells in especially wrong places should be killed permanently with something like laser cavitation, liposuction or cryolipolysis ...Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-19765047697708527192015-04-19T05:02:36.120-07:002015-04-19T05:02:36.120-07:00I wrote a post on this few years ago after I found...I wrote a post on this few years ago after I found that extremely low insulin levels can cause apoptosis in fat cells. I speculated that people going on pure fasts might get their insulin levels low enough to cause apoptosis in fat cells.<br /><br />Although Sidereal later informed me she found several other accounts of people attempting pure fasts and it didnt work out so well for them, and some of them died.<br /><br />If theres one thing thats clear its that males do substantially with fasting than females. Add to that genetics and it gets complicated. We must careful not to use statistical outliers as our basis for analyzing why the general population can or cant do something.<br /><br />As an example, its well documented that after weight loss, some people need surgery, while others dont because their fat and skin "snaps" back into place very well. <br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-84794209875205545402015-04-18T19:50:46.256-07:002015-04-18T19:50:46.256-07:00Kindke, I too believe that fat cells have a set po...Kindke, I too believe that fat cells have a set point for fat but how does this explain individuals have starved themselves to a normal weight? (Im not talking about 500-1500 cal diets, like total starvation for weeks). Mind you, it is not common at all (well documented anyway). Are there fat cells somehow reset? Or do they leave the body? Im not suggesting its healthy at all, far from it, but humans didnt always have abundant food supplies and obesity wasnt a problem. I have found an article based on AB Scotsman and there was an AMA done a while ago http://www.reddit.com/r/IAmA/comments/1o5ndh/iama_guy_who_went_from_430_pounds_to_170_pounds. Something Ive been pondering and would like your opinionAnonymoushttps://www.blogger.com/profile/08634599933022389866noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-15447195160617890142015-04-18T13:49:05.792-07:002015-04-18T13:49:05.792-07:00yohimbine is useless ive tried it.
temporarily us...yohimbine is useless ive tried it.<br /><br />temporarily using a drug to lower the amount of fat in a fat cell will not work longterm because as soon as you stop the drug the fat will come back. fat cells have a "set-point" for the amount of fat it will store that is atleast in part determined by the histone acetylation of the PPARg gene. <br /><br />there are no effective weight loss drugs on the market at the moment. even DNP does not produce weight loss in everyone.Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-39381474766684646612015-04-16T15:01:25.383-07:002015-04-16T15:01:25.383-07:00Kindke this is all so depressing! Makes me even mo...Kindke this is all so depressing! Makes me even more determined to keep this weight off. What do you think of Lyle McDonald's work? He has added a patch to his stubborn fat solution http://www.bodyrecomposition.com/the-stubborn-fat-solution-patch-1-1/. Its only a booklet and I assume it's going to be a hack using some kind of med that either I can't get in my country or will cause interactions with other meds, eg yohimbine, The alternative is - "Rauwolscine HCL: targets visceral fat (fat that is stored in the ‘stubborn areas’ ex- buttocks, stomach and waist). It also acts as a central nervous system stimulant with out the side effects normally associated with strong stimulants (ex- no crash or jitters).*" but impossible to get on it's own, it's always mixed with other thermo ingredients.JasmineJohendhttps://www.blogger.com/profile/11807503482277639920noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-70005636572554959972015-04-15T17:28:40.444-07:002015-04-15T17:28:40.444-07:00A decrease in leptin and hyperplasia are indeed th...A decrease in leptin and hyperplasia are indeed the reason maintaining weight loss is nigh impossible. <br /><br />everyone can lose wt by starving themselves but you cant starve yourself forever and calorie restriction simultaneously decreases leptin and increases AgRP which leaves a "fat debt collection program" in your adipocytes so that if you ever start to increase your food intake, calories are quickly shunted there.<br /><br />Despite what ppl think "starvation mode" is actually real and is mediated by the neuropeptide AgRP.<br /><br />Actually the main job of leptin is purely to counter-act AgRP, because if you delete AgRP in ob/ob they suddenly become normal and regain fertility. It seems the body is set up to naturally assume you are always starving and will only think otherwise when it sees leptin.<br /><br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-76586482925256378022015-04-15T17:10:01.992-07:002015-04-15T17:10:01.992-07:00"The general consensus at the moment seems to..."The general consensus at the moment seems to be that hyperplasia happens when an individual has reached obesity"<br /><br />actually this study disproves that as you can see pre-adipocytes already have the signal to differentiate within 1-3 days of HFD exposure, long before the rodents are "obese". but it may take them 7-8 weeks to complete differentiation and store fat, so I guess that is where the confusion may lie. A few days of binging on processed carbs might take 7-8 weeks before it shows up on your wasitline. I doubt many people would be able to remember what they ate 2 months ago, So if you wake up one day and find yourself a bit fatter, this can explain it, even if youve been eating clean lately.<br /><br />Also the authors state the idea that hyperplasia occurs when exsisting fat cells are "full" also turns out to be false<br /><br />""It has been hypothesized that once adipocytes reach their maximal size they stimulate the production of new adipocytes Our data show, however, that at the onset of diet-induced obesity, adipogenesis is initiated long before existing adipocytes reach their maximum lipid-filling capacity.""<br /><br />I agree that obesity progresses gradually, I dont think you recruit all your pre-adipocytes at once. Mature adipocytes cannot undergo mitosis and once mature they live out thier lives they die, which is approx 10 yrs. However I think before they die they flag another pre-adipocyte to differentiate to take its place.<br /><br />Also I suspect pre-adipocytes undergo mitosis before they differentiate into adipocytes otherwise youd run out of pre-cursor cells.<br /><br /><br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-77129420960380429652015-04-15T15:29:28.227-07:002015-04-15T15:29:28.227-07:00The general consensus at the moment seems to be th...The general consensus at the moment seems to be that hyperplasia happens when an individual has reached obesity. Why then, is it so difficult to keep off 10-15kgs even? I suspect it may be gradual, not all at once when you reach obesity. What do you think?Anonymoushttps://www.blogger.com/profile/08634599933022389866noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-3667449302332108022015-04-15T15:00:15.853-07:002015-04-15T15:00:15.853-07:00Wow, no wonder staying non-obese after weight loss...Wow, no wonder staying non-obese after weight loss is so hard. Thanks for the article.Larcanahttps://www.blogger.com/profile/10109743909244156390noreply@blogger.com