tag:blogger.com,1999:blog-827769867360256958.post7829395638775706926..comments2024-01-14T03:16:09.597-08:00Comments on Kindke's Scrap Notes: Do these people need to go on a diet?Kindkehttp://www.blogger.com/profile/15841418412425329998noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-827769867360256958.post-701654293510983592016-02-04T06:07:33.839-08:002016-02-04T06:07:33.839-08:00Yeah, it's not really something I'd worry ...Yeah, it's not really something I'd worry horribly about. Except maybe under extreme conditions--extreme depletion of fat stores, maybe at some point de-differentiated adipocytes would be a larger fraction of the preadipocyte pool?<br /><br /> But if you look at what happens with white blood cells--the so-called "resetting" of the immune system, where people end up with a lower white blood cell count, but hopefully of a better quality, or at what some of the ketogenic diet/fasting for cancer proponents suggest will happen with prolonged fasting and mitochondria--less, but healthier mitochondria from which to rebuild when refeeding--maybe there'd be something in place to keep the preadipocyte pool from getting too large, anyways.donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-17406241673398660262016-02-03T14:06:23.793-08:002016-02-03T14:06:23.793-08:00yes I have thought about that pre-adipocytes can u...yes I have thought about that pre-adipocytes can undergo mitosis potentially increasing the total number of cells that can differentiate into fat cells however I think this line of thinking is scare mongering because even when you have alot of differentiated mature adipocytes id expect the pool of pre-adipocytes available is still very significant, so if a few de-differentiate back into pre-adipocytes how significant is that? adding a few to many ?<br /><br />also its entirely possible that de-differentiated adipocytes retain an increased tendency and sensitivity to differentiate back into mature adipocytes so you definitely wouldnt want them multiplying in the de-differentiated state.<br /><br />i think this inherent vulnerability of pre-adipocytes being sensitive to differentiation is likely where all the trouble starts and the obesity susceptibility stems from. what causes this vulnerability? probably both genetic and epigenetic markers.<br /><br />fat people give birth to fat babies, and I think the babies inherent the sensitive pre-adipocyte cell pools from their parents.<br /><br />even if your thin in normal life, epigenetic switching via diet might infect your pre-adipocyte cell pools making you fat, you then pass on those infected epigenetically switched cell pools to your offspring, in this way temporary exposure to a fattening diet can propagate down generations even if the obesogenic stimulus was very temporary.Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-84722734145575982612016-02-03T01:33:07.909-08:002016-02-03T01:33:07.909-08:00This comment has been removed by a blog administrator.Chloehttps://www.blogger.com/profile/03940475198510955926noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-11841322190387115852016-01-31T06:30:14.009-08:002016-01-31T06:30:14.009-08:00But there's a dark side to de-differentiation....But there's a dark side to de-differentiation.<br /><br />"New fat cells constantly arise from a preexisting population of undifferentiated<br />progenitor cells or through the dedifferentiation of adipocytes to preadipocytes,<br />which then proliferate and redifferentiate into mature adipocytes" <br /><br />Some more but--one of your other most recent posts looked at rats after lipectomy, a high fat diet prevented the recovery of body fat that came when rats were fed a standard high-carb chow. Maybe this is similar to the "glucose feeds cancer" thing--this could be a circumstance where a diet less conducive to proliferation is protective.<br /><br />Sorry I don't have a link, my source came in as a download from Google, so the link might not work for you. But this is the title and the author's name so you can google it yourself.<br /><br /> Adipocyte Differentiation<br /> José María Moreno-Navarrete and José Manuel Fernández-Real donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-13050335167517520302015-12-30T09:42:12.805-08:002015-12-30T09:42:12.805-08:00For me it is amazing that the people on pictures ...For me it is amazing that the people on pictures are patients with the diagnosis of a cohen syndrome, and their totally usual body shapes are attributed to their condition. Majority of young females look like picture #2, and there are a lot of pre-teens with bodies as shown on the picture #1. The people with a cohen syndrome have a poor glucose tolerance according to the linked paper, may be healthy people with such fat distribution pattern just don't tolerate well the amount of glucose/carbs they eat?<br />Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-43341801053172089672015-12-26T03:53:03.835-08:002015-12-26T03:53:03.835-08:00Great post....very thought provoking. I've wat...Great post....very thought provoking. I've watched quite a few people change their shape and then rebound, likely due to this phenomena. I've also seen people after liposuction gain fat in other areas of the body.<br />So, in fact that is probably the key...de-differentiation, eh?Larcanahttps://www.blogger.com/profile/10109743909244156390noreply@blogger.com