tag:blogger.com,1999:blog-827769867360256958.post9014570926605908485..comments2024-01-14T03:16:09.597-08:00Comments on Kindke's Scrap Notes: Why does glucose make fat?Kindkehttp://www.blogger.com/profile/15841418412425329998noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-827769867360256958.post-28667964819996295682015-02-24T07:42:44.232-08:002015-02-24T07:42:44.232-08:00This comment has been removed by the author.Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-54097918205258209812015-02-24T07:42:17.605-08:002015-02-24T07:42:17.605-08:00ive tried pretty much all the bodybuilding cutting...ive tried pretty much all the bodybuilding cutting drugs and none worked to remove my adipocyte hyperplasia. <br /><br />the best cutting drug ive used so far is melanotan 2, followed by DNP , however DNP is quite brutal and you can get similar results from strict low carb and exercise.<br /><br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-27908025477200950782015-02-09T09:44:49.769-08:002015-02-09T09:44:49.769-08:00Damn... The only way to permanently get rid of mat...Damn... The only way to permanently get rid of mature adipose cells is liposuction and then stay on low GI eating plan for life.<br />Bodybuilders can "cut" to very low BF using some sort of pharma. Is there a way to maintain this result without staying on drugs for life?Alexeyhttps://www.blogger.com/profile/16851238587740739461noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-24612605990591380072015-01-18T12:35:48.139-08:002015-01-18T12:35:48.139-08:00PPARg is complicated, it has 2 different isoforms,...PPARg is complicated, it has 2 different isoforms, and it is isoform 2 that is related to fat storage in adipocytes.<br /><br />Also PPARg forms a heterodimer with retinoid receptors, further, different ligands can be bind to PPARg and this will invariably cause it to bind to different gene's. <br /><br />PPARg has also be seen to be involved in adipocyte apoptosis. <br /><br />the bottom line however is that PPARg targets gene's that increase glucose uptake, triglycerde synthesis and lipid droplet protein synthesis, all things which essentially equate to fat storage.<br /><br />As I said, you have to go back to the other study that looked at why adipocytes incubated in identical growth and culture media come out and at different sizes. Its because the internal gene expression of the cells was different, and they found the association with PPARg was a strong determinant of the fat storage of the cell.Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-89844575461750410872015-01-02T08:23:47.776-08:002015-01-02T08:23:47.776-08:00PS: should have put "See links below" im...PS: should have put "See links below" immediately after the word "peppers"; i.e. the links refer to those substances v/v PPAR-gamma, not those substances v/v obesity/adiposity. Alan2102https://www.blogger.com/profile/03077725184637352859noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-8995696832566171982015-01-02T04:29:02.244-08:002015-01-02T04:29:02.244-08:00Kindke, I'm having a problem with this idea th...Kindke, I'm having a problem with this idea that PPAR-gamma-is-the-bad-guy-that-makes-us-fat. I keep running into things that are inconsistent with that, even directly contradictory to it.<br /><br />PPAR-gamma is upregulated by a wide variety of generally beneficial compounds: flavonoids, polyphenols, curcumin, EGCG and others, including spices like peppers. Some of these compounds have accumulating evidence for a beneficial effect in obesity/adiposity. See links below. Even if these compounds do not actively oppose obesity, they certainly do not promote it.<br /><br />I really don't know. At this moment I am firmly uncommitted.<br /><br />.....................<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/23498665<br />Modulation of adipose tissue inflammation by bioactive food compounds.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/23990052<br />Epigallocatechin-3-O-gallate, a green tea polyphenol, induces expression of pim-1 kinase via PPAR-gamma in human vascular endothelial cells.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/25132338<br />Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-gamma activation.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/24770838<br />Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-gamma in rats subjected to experimental hyperlipidemia and obesity.<br />"CONCLUSIONS:<br />The results indicate that HAEPA exhibits hypolipidemic activity probably by increasing the mRNA expression of adiponectin and PPAR-gamma, which reduce the risk of hyperlipidemia and obesity."<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/25055851<br />Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model.<br />snip<br />"CONCLUSIONS:<br />W-LHIT significantly and safely reduced body weight, normalized glucose and cholesterol levels in obese mice, without suppression of appetite, and increased adipocyte PPAR-gamma and FABP4 gene expression."<br />Alan2102https://www.blogger.com/profile/03077725184637352859noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-77395933907920294012014-11-24T14:42:53.455-08:002014-11-24T14:42:53.455-08:00aye I think any dietary intervention that causes s...aye I think any dietary intervention that causes suppression of PPARg and causes weight loss will fail once that intervention is stopped. Lowcarb works by lowering insulin which lowers PPARg, and we all know if you go back to eating carbs, the weight comes back.<br /><br />I think this PPARg theory is a very good explanation for the elevated fat mass setpoints obese people have. In this context, the cure to obesity is removing the DNA chromatin modifications to the PPARg gene that are causing PPARg to be upregulated.<br /><br />Although I have no idea how and if its possible to reverse these changes, im pretty sure its the hyperinsulinemia and hyperglycemia that is CAUSING these changes. Me and Woo have agreed on many occasions that somehow insulin/obesity seems to "permanently" scar and stretch the adipose tissue. histone acetylation of the PPARg gene I think is how this is happening.<br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-62157915822312738922014-11-24T07:07:31.060-08:002014-11-24T07:07:31.060-08:00terrific find (and i appreciate how you make it ea...terrific find (and i appreciate how you make it easily understood, too)! i think Jaz's "depressing" part is just that we CAN'T go back to regimens that caused us to gain weight in the first place, once we manage to take it off -- which is why i get mad at plans like Weight Watchers who never tell their people they have to change their diets "forever" ... they don't make people change AT ALL.tesshttps://www.blogger.com/profile/04254045589639201707noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-53217119772814095292014-11-23T13:38:54.792-08:002014-11-23T13:38:54.792-08:00Thanks Kindke..depressing for us weight reduced pp...Thanks Kindke..depressing for us weight reduced pple.JasmineJohendhttps://www.blogger.com/profile/11807503482277639920noreply@blogger.com