tag:blogger.com,1999:blog-827769867360256958.post9120818170398445098..comments2024-01-14T03:16:09.597-08:00Comments on Kindke's Scrap Notes: What is "Fat-mobilizing substance" ???Kindkehttp://www.blogger.com/profile/15841418412425329998noreply@blogger.comBlogger13125tag:blogger.com,1999:blog-827769867360256958.post-16750040726628164652013-06-14T05:51:19.979-07:002013-06-14T05:51:19.979-07:00Great post, Kindke.
Reducing calories on a high c...Great post, Kindke.<br /><br />Reducing calories on a high carb diet improves metabolic efficiency, but reducing calories on a high fat diet doesn't affect metabolic efficiency. OK. This jives with some of the more recent energy balance studies (http://caloriesproper.com/?p=2352), although K&P attribute it to urinary carbon loss as opposed to energy expenditure? Interesting.<br />Billhttps://www.blogger.com/profile/05022558754270362782noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-85691933678774854472013-06-13T14:29:31.916-07:002013-06-13T14:29:31.916-07:00Im not sure of anything here myself tbh, it may no...Im not sure of anything here myself tbh, it may not be of "pituitary origin", the only thing Kekwick and Pawan say is that a functioning pituitary was necessary for its presence in urine during fasting. And it is absent from urine in fasting with Hypopituitarism.<br /><br />Best & Campbell noted that it was present in certain extracts of the anterior pituitary gland which however does suggest it might be of pituitary origin. <br /><br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-61919881904375278732013-06-13T13:48:52.129-07:002013-06-13T13:48:52.129-07:00Are we sure it's of pituitary origin? It seems...Are we sure it's of pituitary origin? It seems possible that some product of the pituitary gland (some peptide or whatever from the pituitary encouraging secretion of some other substance elsewhere) is involved.<br /><br />http://joe.endocrinology-journals.org/content/180/3/R1.long<br /><br />"Food restriction regulates adipose-speciļ¬c cytokines in pituitary<br />gland but not in hypothalamus"<br /><br /><br /><br />I know pretty much squat in this area--but it's possible that some sort of fiaf-involved central signal might be involved, affecting fiaf production and appearance elsewhere in the body.donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-16187564235458158912013-06-13T12:24:15.464-07:002013-06-13T12:24:15.464-07:00Oh no. I was hoping for a business opportunity.
...Oh no. I was hoping for a business opportunity.<br /><br />Wait! What if you, hm, well, administer it another way?valeriehttps://www.blogger.com/profile/05234169408257579073noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-74020271718071663402013-06-13T11:42:48.406-07:002013-06-13T11:42:48.406-07:00I wonder, if the lowering of blood sugar is not ob...I wonder, if the lowering of blood sugar is not observe, does it indicate the absence of the mysterious substance? Dr. Eades claimed that his patients were loosing fat from livers.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-47574155943898788162013-06-13T11:31:40.150-07:002013-06-13T11:31:40.150-07:00FIAF is made all over the place, mostly in the liv...FIAF is made all over the place, mostly in the liver, WAT, and as Kindke said, the gut...Purposelessnesshttps://www.blogger.com/profile/05310957056111105419noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-60304317071520731512013-06-13T11:23:20.969-07:002013-06-13T11:23:20.969-07:00Wasnt that one secreted by the gut? This one is re...Wasnt that one secreted by the gut? This one is reported to be of pituitary origin, <br /><br />Strangely a pubmed search for beta lipotropin lists some of the older studies by kekwick and pawan which is rather strange, since I dont think they ever actually named it.Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-61632990819216862602013-06-13T08:50:26.205-07:002013-06-13T08:50:26.205-07:00could it be the FIAF that Peter describes? could it be the FIAF that Peter describes? tesshttps://www.blogger.com/profile/04254045589639201707noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-80916798481070502902013-06-13T04:42:53.065-07:002013-06-13T04:42:53.065-07:00Oh well. I'll read the paper, maybe something ...Oh well. I'll read the paper, maybe something else will come to mind..Purposelessnesshttps://www.blogger.com/profile/05310957056111105419noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-22989868349410677692013-06-13T04:34:35.086-07:002013-06-13T04:34:35.086-07:00It is lipolytic in rabbits: http://www.ncbi.nlm.ni...It is lipolytic in rabbits: http://www.ncbi.nlm.nih.gov/pubmed/2210032<br />and increases ketogenesis: http://www.ncbi.nlm.nih.gov/pubmed/6717761<br /><br />Here is a strange abstract on the hormone and food motivation: http://www.ncbi.nlm.nih.gov/pubmed/7326405<br /><br />A quick search revealed nothing about blood sugar though, let alone lipotropin injections..Purposelessnesshttps://www.blogger.com/profile/05310957056111105419noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-1268214391838352712013-06-13T04:30:14.730-07:002013-06-13T04:30:14.730-07:00I also forgot to mention that Kekwick and Pawan sa...I also forgot to mention that Kekwick and Pawan say that fat-mobilizing substance is de-activated by trypsin so you cannot drink your own urine to recycle this fat burner.Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-20720679010533864182013-06-13T04:28:28.717-07:002013-06-13T04:28:28.717-07:00Could be!, although the wiki entry says lipotropin...Could be!, although the wiki entry says lipotropin produces steroidogenesis but Kekwick and Pawan say<br /><br />"However, it is not identical with corticotrophin, since it exhibits none of the usual steroid-like effects in the intact animal, has only very low activity in releasing steroids from viable adrenal tissue, and after inactivation by hydrogen peroxide cannot be reactivated with cysteine."Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-72068404690730641112013-06-13T04:07:48.288-07:002013-06-13T04:07:48.288-07:00Beta-Lipotropin comes to mind. It is produced in t...Beta-Lipotropin comes to mind. It is produced in the pituitary and has something to do with lipolysis, but I never looked into it and the wikipedia article is very short: http://en.wikipedia.org/wiki/LipotropinPurposelessnesshttps://www.blogger.com/profile/05310957056111105419noreply@blogger.com