tag:blogger.com,1999:blog-827769867360256958.post406957631857291123..comments2024-01-14T03:16:09.597-08:00Comments on Kindke's Scrap Notes: Another look at why LIRKO cant get fatKindkehttp://www.blogger.com/profile/15841418412425329998noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-827769867360256958.post-46496539602321710852012-12-08T09:09:36.633-08:002012-12-08T09:09:36.633-08:00Im inclined to think its someone fooling around bu...Im inclined to think its someone fooling around but the comments were written with a sensible tone.<br /><br />hhhhhhhmmmmmmmmKindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-38656919718720085382012-12-08T08:39:03.674-08:002012-12-08T08:39:03.674-08:00The senior author (or someone taking the piss?) sh...The senior author (or someone taking the piss?) showed up on Carbsane's blog.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-827769867360256958.post-251870099676261672012-12-08T05:07:54.949-08:002012-12-08T05:07:54.949-08:00OK after Sidereal sent me the full text I see that...OK after Sidereal sent me the full text I see that what really happened was rosiglitazone caused apoptosis in fat cells in control mice but only increased fat cell size in LIRKO mice, although I was wrong in my initial speculation as to what was happening, what is clear however is that functional insulin signalling in the liver is indeed required in order for PPARĪ³ in adipose tissue to work correctly. <br /><br />So again this points out that using the LIRKO mouse model with hyperinsulinemia to somehow "prove" that insulin doesnt cause obesity, is also a flawed proposal.<br />Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.com