Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.

I havent seen this study before. So hepatic IR is indeed the cause of metabolic syndrome. But we already know what causes liver insulin resistance, it is elevated ChREBP in the liver, which essentially derives from a combination of high carbohydrate consumption, and also frequent carbohydrate consumption.

EDIT:

I just had this flash up aswell..

Hepatic insulin resistance directly promotes formation of cholesterol gallstones.

From reading the abstract its our old friend FoxO1 which causes this, as in metabolic syndrome, hyper-active FoxO1 promotes gallstone formation.