During my research into steroids one of the more interesting studies that cropped up was this.....
Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males.
Aromasin is an aromatase inhibitor, it works by binding irreversibly to the aromatase enzyme, so that other steroids like testosterone cant bind to it. In this study young males were given 25mg per day ( which is the standard tablet size ) for 10 days.
At the end of the 10 days, total testosterone had increased ~60% but free testosterone ( that is, the testosterone that is actually free to bind the androgen receptor ) increased by 117%. The reason this works is because estrogen is reduced as a result of the aromatase blockage, and estrogen is the main negative feedback signal to the hypothalamus to decrease LH secretion. So with lower estrogen in the system, more LH is secreted and more testosterone is made. Its a double whammy aswell, because with aromatase blockage, less testosterone is lost in the conversion to estrogen.
Infact another recent report even suggested aromatase inhibitors may be of benefit to obese men who suffer from hypogonadism due to the excess estrogen that usually accompanies obesity.
Whether or not this increased testosterone will result in anabolic affects however is up for debate. However if you think your suffering from low testosterone, aromasin could be of some help. Aromasin is actually quite a safe drug, with minimal side affects, but it is slightly pricey.
Note in the first study, estrogen levels returned to normal 3-6 days after aromasin withdrawal, so the drug must be continuously taken to keep the increased levels of testosterone. Bear in mind also, estrogen is actually a very important hormone in men, lower is not necessarily better. Low estrogen will absolutely murder your sex drive and ability to get an erection, in a similar way low testosterone will.