Tuesday, 3 April 2012

Stuffed with fat and insulin Resis..........Er Sensitive!

I havent seen this paper discussed before. You know all those theories floating about how stuffing cells full of fat makes them insulin resistant, well its obvious why! Because of excess energy availability! Duh.


Once again we see a perfect example of how humans are just in general wrong. Much more often than not. The more you observe and measure something, the more likely you are to be wrong, atleast in mind and theory. Is there any wonder why trading is so hard, the more you look at the charts the more likely you are to be wrong.

Anyway, in this paper the researchers deleted the Adipose triglyceride lipase gene in mice, this is an important enzyme for the breakdown of triglyceride, and without it, your FAT!.

These fat greedy little beasties had reduced energy expenditure, and massive stores of ectopic fat, I.E. massive stores of fat in other places other than adipose tissue, aswell as increased circulating free fatty acids ( compared to mutant ATGL -/- mice that were fed a low-fat diet ). This is certainly what most top doctors would call a "lipotoxic environment", and these greedy fat mice should be intensely diabetic. Theres just one problem...

They aint.

Nope, no siree! Infact they are more insulin sensitive than thier skinny chow fed litter-mates! Funny that. So, where are they more insulin sensitive exactly? Well, in the Liver, Adipose tissue, and heart.

Importantly, the researchers make the point that skeletal muscle was more insulin sensitive in vivo than ex vivo, suggesting that some circulating factor helps contribute to insulin sensitivity in skeletal muscle ( most likely Adiponectin ).

Here is the real kicker....
In fact, ATGL−/− mice fed a high-fat diet were more insulin sensitive than Wt mice fed a low-fat diet.
Thats it folks. Throw out all your biology and physiology text books. Thier all wrong.

1 comment:

  1. Hmmm perhaps this specific gene is important in controlling the shift of physiology from fat storing to fat breakdown. The mice store fat uncontrollably and are increasingly sensitive to insulin as lack of gene activity is telling the body "STORE FAT LOTS OF IT PLZ".

    More evidence that the "diseases of obesity" are a horrible misnomer; the problem is when you can't compensate for metabolic disorder with fattening.