Thursday, 11 August 2011

GLP-1 strikes again!

A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.

"Daily administration of this antagonist by subcutaneous injection to diet-induced obese mice for 1 week caused a significant increase in food intake, body weight, and glucose intolerance, demonstrating endogenous GLP-1 as a relevant hormone in mammalian energy balance in the obese state."

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