Wednesday, 15 May 2013

SCFA's inhibit insulin signalling in fat cells

I havent seen this study reported anywhere else in the blogosphere!

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.

 Hence, this report also supports our results that suppression of adipose insulin signalling by GPR43 activation leads to prevention of obesity and improves systemic insulin sensitivity.

Look at how blasphemous this statement is, suppression of insulin signalling in adipose tissue prevents obesity.    lol  whha  ??!?!?!?!?!!!!?

Anyway, to cut a long story short, GPR43 is a receptor for short-chain fatty acids including acetate, and is expressed in various tissues including the adipocyte. There was some controversy surrounding the function of GPR43 in adipocytes because in vitro studies had shown that it promoted adipogenesis, but this research group claims to have shown that the in vitro observations of GPR43 do not match those of in vivo.

This study seems to support the nutrient partitioning idea, as GPR43 not only suppresses insulin signalling in adipocytes but improves systemic insulin signalling including in the muscle.

One observation I would like to make however, is that I have tried on numerous occasions high dose inulin for several days/weeks at a time but did not notice a reduction in fat mass.



  1. wouldn't be the first time that what happens in a petri-dish doesn't match what happens in the body.... [smirk]

  2. I wonder if supplementing SCFAs would do anything? -->

    butyric acid seems to be available

    Awesome find Kindke!

    1. i thought about that especially since there was another study showing how butyrate supplementation in the diet prevents obesity

      mice were put on HFD supplemented with molarity-matched sodium salts of butyrate (5% w/w), propionate (4.3%), and acetate (3.7%) for four weeks. As expected, mice on control HFD gained weight steadily over time. Dietary supplementation of butyrate and propionate completely blocked HFD-induced weight gain, while acetate led to a 40% suppression of excess weight gain

      Those pills are definitely too small a dose. Perhaps someone will come up with a "butyrate" supplement drink. could be interesting.

  3. I've noticed fiber consumption definitely seems to attenuate hunger and weight, and trust me I am not one to believe in "feel good" dietary myths but the effect for me is obvious.

    It may be the case where you need protective GI flora to benefit from fiber supplementation, otherwise increasing fiber intake is useless or even counterproductive. Case in point, when I am coming off of a work marathon and prolonged insufficient sleep, I develop signs/symptoms of SIBO like condition. My GI flora seems to become quite unbalanced, I experience bloating and intestinal discomfort and malaise eating all foods but particularly fiberous food.

    On the other hand, when sleeping some what normally to correct immune system, and meal time architecture is more rational with prolonged periods of food avoidance, I do not at all respond this way to fiberous foods and intestinal complaints much better.

    I suspect dairy is very big at promoting SIBO, most of us really do not completely digest dairy and the constant influx of low grade undigested dairy products promote SIBO as well as nebulous complaints like lethargy, mental dimming, malaise, bloating/gas. Keeping my diary consumption to lower levels helps SIBO very much, whereas if I am eating lots of dairy (enough for flora to be out of wack) and then pile on fiber, the fiber only helps worsen the condition.

    And of course, sleep deprivation interacts with all of the above, as the immune system is culprit #1 in regulating gut microbes; so sleeping normally and GI result is totally incomparable to sleeping deficient and eating similar foods. For example, I can "tolerate" dairy while mostly sleeping sufficiently, but 3 or 4 days of sleeping 5 or 4 hrs a night on average, I can't.

  4. Have you tried vinegar? Acetic acid is a short chain fatty acid.
    There is a report of someone damaging her teeth with frequent vinegar drinking, though.