The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.
Hence, this report also supports our results that suppression of adipose insulin signalling by GPR43 activation leads to prevention of obesity and improves systemic insulin sensitivity.
Look at how blasphemous this statement is, suppression of insulin signalling in adipose tissue prevents obesity. lol whha ??!?!?!?!?!!!!?
Anyway, to cut a long story short, GPR43 is a receptor for short-chain fatty acids including acetate, and is expressed in various tissues including the adipocyte. There was some controversy surrounding the function of GPR43 in adipocytes because in vitro studies had shown that it promoted adipogenesis, but this research group claims to have shown that the in vitro observations of GPR43 do not match those of in vivo.
This study seems to support the nutrient partitioning idea, as GPR43 not only suppresses insulin signalling in adipocytes but improves systemic insulin signalling including in the muscle.
One observation I would like to make however, is that I have tried on numerous occasions high dose inulin for several days/weeks at a time but did not notice a reduction in fat mass.