Sunday, 14 November 2010

Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

http://www.ncbi.nlm.nih.gov/pubmed/11872656

"Plasma concentrations of amino acids are frequently elevated in insulin-resistant states, and a protein-enriched diet can impair glucose metabolism"

"In conclusion, plasma amino acid elevation induces skeletal muscle insulin resistance in humans by inhibition of glucose transport/phosphorylation, resulting in marked reduction of glycogen synthesis"

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