Insulin and Leptin is needed for Fertility

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.

" the physiological significance of concomitant leptin and insulin action on POMC neurons remains to be established"

"Here, we show that mice lacking both leptin and insulin receptors in POMC neurons display systemic insulin resistance, which is distinct from the single deletion of either receptor."

"We conclude that direct action of insulin and leptin on POMC neurons is required to maintain normal glucose homeostasis and reproductive function"