Monday, 22 November 2010

2,4-Dinitrophenol - The anti obesity drug thats been known since 1930

http://www.ncbi.nlm.nih.gov/pubmed/20953861

This report makes for a very interesting read and it looks like uncoupling proteins could be the answer for fat loss.

Thursday, 18 November 2010

Sunday, 14 November 2010

Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

http://www.ncbi.nlm.nih.gov/pubmed/11872656

"Plasma concentrations of amino acids are frequently elevated in insulin-resistant states, and a protein-enriched diet can impair glucose metabolism"

"In conclusion, plasma amino acid elevation induces skeletal muscle insulin resistance in humans by inhibition of glucose transport/phosphorylation, resulting in marked reduction of glycogen synthesis"

Saturday, 13 November 2010

Surplus dietary tryptophan inhibits stress hormone kinetics and induces insulin resistance in pigs

http://www.ncbi.nlm.nih.gov/pubmed/19615391

"In conclusion, long-term feeding of surplus dietary TRP inhibits both baseline adrenocortical and sympathetic nervous system activity, it induces insulin resistance for both glucose and amino acid clearance but it does not affect whole body protein catabolism"

Move support not to over-indulge in the protein.

Low-carbohydrate diet disrupts the association between insulin resistance and weight gain.

http://www.ncbi.nlm.nih.gov/pubmed/19439329

"the heavier animals that were fed LFD had impairment in insulin sensitivity, which was not observed in those fed LCD"

"The weight gain in animals fed LCD may be related to their greater caloric intake, lower levels of glucagon-like peptide-1, and higher protein consumption"

"The adoption of LCD promotes a unique metabolic state that prevents insulin resistance, even in guinea pigs that gained more weight."

"The association between weight gain and insulin resistance seems to be dependent on high carbohydrate intake"

Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats

http://www.ncbi.nlm.nih.gov/pubmed/19219861

Good news for coconut oil I guess?

Diet-induced obese mice are leptin insufficient after weight reduction.

http://www.ncbi.nlm.nih.gov/pubmed/19373220

This is scary news for people who lose weight by dieting and helps explains why people gain fat mass back.

Get your leptin checked after loosing weight by dieting.